What is breast density and why is it important?
Breast density refers to the relative proportion of the three main contents of the breast: 1) milk-producing glandular tissue and ducts, 2) stroma—the internal scaffolding of the breast that holds everything in place, and 3) fat tissue which serves as a filler to keep the breast soft and pliable. Breasts that have a relatively high proportion of fat tissue are considered “fatty” or “non-dense,” and breasts that have more glandular tissue and stroma are considered “dense.”
Breast density tends to be higher in premenopausal women and in women taking hormone replacement therapy. As women age, the glandular and stromal components of the breast tend to disappear and the fat component tends to predominate. However, some young women have fatty breasts and some elderly women have dense breasts. Breast density patterns also tend to run in families, so women are likely to notice breast densities similar to their mother or sister.
Efforts to increase public awareness of breast density are also motivated by its association with an increased risk of breast cancer. In fact, women with dense breasts are four times more likely to develop breast cancer than women with fatty, less dense breasts. In addition, breast tissue density influences the ability of both physical examination and screening imaging tools to detect the presence of breast cancer.
The four levels of breast density that may be detected in mammograms. Levels 3 and 4 should be disclosed to doctors and their patients.
How is breast density measured?
Breast density is divided into 4 levels based upon the amount of glandular tissue and stroma compared to the amount of fatty tissue contained within the breast (See Image Above).
The effort to improve breast cancer detection led California legislators to pass the California Breast Density Law, which requires mammography providers, beginning April 1, 2013, to notify women if they have Level 3 or Level 4 breast density. The law also mandates that women must also be notified that high breast density may increase their risk of breast cancer and that dense breast tissue can make it harder for mammograms to detect cancer.
The Breast Density Law was originally scheduled to expire on January 2019, but legislation (SB-1034) was introduced by Senator Holly J. Mitchell (Los Angeles) to remove the law’s sunset clause before it was ultimately re-enacted by Gov. Jerry Brown, ensuring that the law will stay in effect until January 2025. Notably, the legislation explicitly states that the law “shall not be deemed to a create a duty of care or other legal obligation” beyond the duty of mammography centers to notify patients and their providers of the hazards of high breast density.
A major shortcoming of the Breast Density Law is that it does not provide guidance on how dense breast patients and their physicians should address the shortcomings of mammography nor require insurance companies to cover the cost of adjunctive breast imaging, creating a dilemma for patients and physicians trying to navigate this conundrum. To provide an evidence-based rationale to approaching this discussion, the U.S. Preventive Services Task Force (USPTF) conducted a systemic review of supplemental screening for breast cancer in women with dense breasts, which identified screening ultrasound, contrast-enhance breast MRI, and digital breast tomosynthesis (3D mammography) as the most useful adjunctive technologies for screening of women with dense breasts. For example, for every 1,000 mammographic examinations, adjunctive screening ultrasound was capable of detecting 4.4 additional cancers, MRI 3.5-28.6 additional cancers, and 3D mammography 1.4-2.5 additional cancers. The USPTF recognized the potential for false-positive results and unnecessary biopsies, but acknowledged that there was “insufficient evidence to assess the balance between benefits and harms of adjunctive screening.”
Ultimately, the decision of if and when to incorporate supplemental screening for dense breast patients requires shared decision-making that is guided by the patient’s personal risk of breast cancer assessed most appropriately utilizing the Tyrer-Cuzick or Breast Cancer Surveillance Consortium (BCSC) breast cancer risk assessment tools, each of which incorporates breast density:
Estimated Lifetime Risk <15% (Average Risk):
Annual digital screening mammography and bilateral screening ultrasound beginning at 40
Estimated Lifetime Risk 15-20% (Moderate Risk, or BCSC Risk >/=1.7% at 5 years):
Annual digital screening mammography and bilateral screening ultrasound beginning at 35, or 10 years before youngest relative but not before age 30
Estimated Lifetime Risk >20% (High Risk):
Annual digital screening mammography beginning at age 30, or 10 years before youngest relative but not before age 30;
Annual bilateral contrast-enhanced breast MRI beginning at 30, or 10 years before youngest relative but not before age 25
One recent development that has complicated the use of annual screening contrast-enhanced MRI in dense breast women is the issue of gadolinium retention in the brain, first reported in 2014. Gadolinium-based contrast agents are essential for MRI imaging of the breasts. Although there is not clinical evidence that directly links gadolinium retention to adverse health conditions in patients with normal renal function, the medical community is beginning to rethink liberal use of breast MRI for high risk screening, particularly for younger women who might otherwise face a long life of yearly screening MRIs. (Gadolinium is contraindicated in women with renal insufficiency.) Gadolinium deposition is an area of active clinical research and the subject of much patient interest. However, in the absence of further guidance, health care providers and patients must participate in shared decision-making to determine if the frequency of breast MRI might be adjusted for an individual patient based on her personal risk and family history of breast cancer, age, and risk-tolerance.
The following considerations must also be given to selecting your personalized screening regimen:
Ultimately, the art and science of medicine is helping you understand your personal breast cancer risk and helping you decide how proactive you should be regarding breast cancer screening. Hopefully, this article has provided a framework for how you may navigate this shared decision-making process with your doctor.
Check out the upcoming issue for a more detailed discussion of breast cancer risk assessment and breast cancer risk reduction.