As National Co-Chair of the TARGIT U.S. Registry clinical trial and President of the TARGIT Collaborative Group, breast surgeon Dennis R. Holmes, M.D., F.A.C.S., is a world-recognized expert in targeted intraoperative radiotherapy (TARGIT) with offices in Santa Monica, Glendale, and Los Angeles, California.
TARGeted Intraoperative radioTherapy (TARGIT) or IORT is a form of breast radiation that is administered as a single treatment at the time of lumpectomy to reduce the risk of cancer recurrence. As a type of partial breast irradiation, TARGIT limits the radiation treatment to the tumor site where the risk of recurrence is highest. This spares the rest of the breast and surrounding tissues (e.g., heart and lung) the side effects of radiation. TARGIT takes only 30 minutes to deliver. By comparison, traditional whole breast radiotherapy administers radiation to the whole breast, chest wall, and to some degree the nearby organs, and takes several weeks to complete.
For most patients, TARGIT completely eliminates the needs for the 3-week or 6-week course of traditional whole breast radiation normally required after lumpectomy surgery.
Also, TARGIT reduces the overall side effects of radiation by confining the radiation dose to the part of the breast from which the cancer was removed, sparing the rest of the breast and surrounding tissues (e.g., heart and lung) the side effects of radiation. However, there are cases of advanced or high-risk breast cancer that benefit from treatment with both TARGIT and whole breast radiation.
The effectiveness of TARGIT was investigated in an international study called the TARGIT-A Trial, a clinical trial that compared partial breast single dose targeted intraoperative radiotherapy (IORT) to 3-6 week post-operative whole breast radiotherapy among women undergoing lumpectomy for early stage breast cancer. The clinical trial publication, which Dr. Holmes co-authored, demonstrated equal breast cancer recurrence rates and equal cancer survival rates among recipients of targeted IORT during lumpectomy compared to those receiving multiple weeks of whole breast radiation after lumpectomy. The paper was published today in the British Medical Journal.
With long term follow-up (median 8.6 years, maximum 18.9 years), the TARGIT-A Trial demonstrated no significant difference in the 5- year local recurrence rates and 8.6 year local-recurrence free survival rate, breast cancer survival rate, and overall survival rate. Women receiving targeted IORT had a significantly lower risk of dying from other causes (e.g., heart disease or cancers). The findings of the TARGIT-A trial are summarized in the following table:
If you’ve been diagnosed with breast cancer and are considering a lumpectomy, you may be eligible for TARGIT if you meet the following criteria:
TARGIT was shown to be as safe as traditional whole breast radiotherapy in a large, international study called the TARGIT-A Trial. More importantly, breast cancer survival was equal between the two treatments and deaths related to heart disease and other cancers were significantly lower among women receiving TARGIT.
"He treated my daughter who had stage one breast cancer. He put us at ease and calmed our fears , he was the perfect surgeon for our situation."
"He has to be one of the most incredible doctor that I've been blessed to have on my survival team. He's saved my life! I'm a proud 28 yr B C survivor."
"Dr. Holmes is kind, professional, and has a lot of patience answering every question you might have."
"Great and SMART staff. Great place with ZERO infection rate. I was back to work after surgery way sooner then expected! Awesome place great center."
“Thank you so much for being caring and patient with me during this hard transition. I really appreciate your professionalism and dedication.”
“God Bless you, your mind, and your hands, so you may continue to help all women with breast cancer! We thank you for everything that you have done!"
"This week I celebrated my 55th birthday. I cannot be thankful enough for your help in giving me another chance to enjoy waking up each day."