Dennis R. Holmes, M.D., F.A.C.S. Glendale, CA Office

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1505 Wilson Terrace
Suite 150
Glendale, CA 91206

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Dennis R. Holmes, M.D., F.A.C.S.

Breast Cancer Surgeon located in Santa Monica, Los Angeles and Glendale, CA

EXPERT. Dr. Holmes is an internationally-renowned dedicated breast surgeon and cancer researcher who has held the position of Breast Center Medical Director at several hospitals in Los Angeles County. Dr. Holmes has also served as Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health and as Chief Breast Cancer Surgeon and Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center. 

FELLOWSHIP-TRAINED. Dr. Holmes is a 2003 graduate of the U.S.C. Breast Surgery Fellowship Training Program, one of the most progressive breast surgeon training programs in the U.S. Breast surgery fellowship training represents not only the highest level of commitment to excellence in breast cancer surgery but also dedication to understanding the roles of medical oncology, radiation oncology, plastic surgery, and other critical services in the management of breast cancer. Since then, Dr. Holmes has integrated this experience into the training of over 20 breast surgeons in his former roles as Program Director of the U.S.C. Keck School of Medicine and John Wayne Cancer Institute’s Breast Surgery Fellowship Programs. 

LEADER. Dr. Holmes serves in the leadership of several national surgical societies and is a frequent lecturer at conferences internationally. Dr. Holmes is a Fellow of the American College of Surgeons and currently serves as President of the TARGIT Collaborative Group, a national intraoperative radiotherapy research and education organization, and Conference Program Chair of the 20th Annual Meeting of the American Society of Breast Surgeons, the nation’s largest breast surgeon society. 

INNOVATOR. Widely respected by colleagues for his innovative approach to breast cancer care, Dr. Holmes has gained worldwide acclaim for his pioneering research in intraoperative radiotherapy and cryoablation (tumor freezing). He currently serves as National Co-Chair of the TARGIT U.S. Registry clinical trial and as National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation instead of surgery for the treatment of early stage breast cancer. In addition, he has been a pioneer in the field of minimally-invasive breast surgery, including intraoperative radiotherapy, oncoplastic surgery, and lymph node-sparing surgery. 

ADVOCATE. Dr. Holmes is a strong advocate for individualized or personalized cancer therapy that adapts the extent of care to the severity of the cancer, minimizing unnecessary side effects. Where many breast surgeons see challenges, Dr. Holmes sees opportunities to optimize cancer control as well as patient quality of life. However, what distinguishes Dr. Holmes most is his high level of commitment to providing women with treatment options that suit their physical and emotional needs while also managing the breast problem effectively. 

MOST OF ALL, Dr. Holmes believes wholeheartedly that, with proper treatment, most women diagnosed with breast cancer will live a long, fulfilling life—a life both richer and more meaningful than they could have imagined following diagnosis. Let your journey begin.

For more information about Dr. Holmes, visit his YouTube Channel here.

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Dennis Holmes, MD, FACS

EXPERT. Dr. Holmes is an internationally-renowned dedicated breast surgeon and cancer researcher who has held the position of Breast Center Medical Director at several hospitals in Los Angeles County. Dr. Holmes has also served as Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health and as Chief Breast Cancer Surgeon and Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center. 

FELLOWSHIP-TRAINED. Dr. Holmes is a 2003 graduate of the U.S.C. Breast Surgery Fellowship Training Program, one of the most progressive breast surgeon training programs in the U.S. Breast surgery fellowship training represents not only the highest level of commitment to excellence in breast cancer surgery but also dedication to understanding the roles of medical oncology, radiation oncology, plastic surgery, and other critical services in the management of breast cancer. Since then, Dr. Holmes has integrated this experience into the training of over 20 breast surgeons in his former roles as Program Director of the U.S.C. Keck School of Medicine and John Wayne Cancer Institute’s Breast Surgery Fellowship Programs. 

LEADER. Dr. Holmes serves in the leadership of several national surgical societies and is a frequent lecturer at conferences internationally. Dr. Holmes is a Fellow of the American College of Surgeons and currently serves as President of the TARGIT Collaborative Group, a national intraoperative radiotherapy research and education organization, and Conference Program Chair of the 20th Annual Meeting of the American Society of Breast Surgeons, the nation’s largest breast surgeon society. 

INNOVATOR. Widely respected by colleagues for his innovative approach to breast cancer care, Dr. Holmes has gained worldwide acclaim for his pioneering research in intraoperative radiotherapy and cryoablation (tumor freezing). He currently serves as National Co-Chair of the TARGIT U.S. Registry clinical trial and as National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation instead of surgery for the treatment of early stage breast cancer. In addition, he has been a pioneer in the field of minimally-invasive breast surgery, including intraoperative radiotherapy, oncoplastic surgery, and lymph node-sparing surgery. 

ADVOCATE. Dr. Holmes is a strong advocate for individualized or personalized cancer therapy that adapts the extent of care to the severity of the cancer, minimizing unnecessary side effects. Where many breast surgeons see challenges, Dr. Holmes sees opportunities to optimize cancer control as well as patient quality of life. However, what distinguishes Dr. Holmes most is his high level of commitment to providing women with treatment options that suit their physical and emotional needs while also managing the breast problem effectively. 

MOST OF ALL, Dr. Holmes believes wholeheartedly that, with proper treatment, most women diagnosed with breast cancer will live a long, fulfilling life—a life both richer and more meaningful than they could have imagined following diagnosis. Let your journey begin.

For more information about Dr. Holmes, visit his YouTube Channel here.


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